Effect of Nifedipine on Dichlorvos-Induced Seizure in Mice

Abstract

Problem statement: Dichlorvos a synthetic organophosphate poisons is the property of insecticide. These toxins as insecticides in agriculture and medicine for animals and the destruction of ectoparasites can be used. Studies have shown that Dichlorvos creation seizure effects in different animals. Nifedipine, dihydropyridine calcium channel blockers, widely used for treatment of cardiovascular diseases. Studies have shown that the calcium channel blockers are anticonvulsant effects in different animal models. The aim of this study was to determine the effect of nifedipine on Dichlorvosinduced seizures in mice. Approach: In this experiment, the animals were received different doses of nifedipine (2.5, 5, 10, 20 and 40 mg kg^-1) intraperitoneally 30 min before intraperitoneal injection of Dichlorvos (50 mg kg^-1). After Dichlorvos injection, clonic and tonic seizures and death was investigated. Results: Results showed that nifedipine dose dependently reduced the severity of Dichlorvos-induced seizures, so that nifedipine dose 10 and 40 mg kg^-1, respectively, the lowest (p<0.05) and highest (p<0.001) had anticonvulsant effects. Conclusion: The anticonvulsant activity of nifedipine suggests that possibly due to antagonistic effect on voltage-dependent calcium channel.