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ISSN: 1557-4563 (Online)
Research Article Open Access

Marking of Genetic Resistance to Chlamydia, Brucellosis and Mastitis in Holstein Cows by Using Polymorphic Variants of LTF, MBL1 and TLR9 Genes

Indira Beishova1, Birzhan Nurgaliyev1, Alena Belaya2, Gulzhagan Chuzhebayeva3, Vadim Ulyanov1, Tatyana Ulyanova1, Alexandr Kovalchuk1, Laura Dushayeva1, Kenzhebek Murzabayev1, Ainura Taipova4, Aizhan Zholdasbekova1 and Azamat Isabaev3
  • 1 Zhangir Khan West Kazakhstan Agrarian Technical University, Uralsk, Kazakhstan
  • 2 Belarusian State Pedagogical University named after Maxim Tank, Minsk, Belarus
  • 3 Kostanay Regional University named after A. Baitursynov, Kostanay, Kazakhstan
  • 4 Kazakh National Agrarian Research University, Almaty, Kazakhstan

Abstract

The purpose of the research is to study the association of polymorphic variants of the Toll-Like Receptor 9 (TLR9), Mannose-Binding Lectin 1 (MBL1), and Lactoferrin (LTF) genes with the incidence of chlamydia, brucellosis and mastitis in Holstein cows. Samples of Holstein cows with established diagnoses of chlamydia, brucellosis, and mastitis were characterized by the nature of the correspondence of the observed frequencies of genotypes theoretically expected by the Hardy Weinberg law, by the percentage of genotypes in comparison with the control group of healthy animals, as well as by the nature of the distribution of relative frequencies of alleles of the studied genes. It was found that the genotypes TLR9-BfaIAA and MBL1-HaeIIICC were the genetic markers of increased resistance to chlamydia. The genotypes TLR9-BfaI AG and MBL1-HaeIIITT were the genetic markers of an increased risk of chlamydia. The genotypes MBL1-HaeIIITT and LTF-EcoRIAA were the genetic markers of an increased risk of brucellosis. The genotypes MBL1-HaeIIITC and LTF-EcoRIAB were the genetic markers of increased brucellosis resistance. The LTF-EcoRIAA genotype was a genetic marker of an increased risk of mastitis and the LTF-EcoRIAB genotype marked increased resistance to mastitis in Holstein cattle.

American Journal of Animal and Veterinary Sciences
Volume 18 No. 2, 2023, 89-97

DOI: https://doi.org/10.3844/ajavsp.2023.89.97

Submitted On: 28 December 2022 Published On: 6 May 2023

How to Cite: Beishova, I., Nurgaliyev, B., Belaya, A., Chuzhebayeva, G., Ulyanov, V., Ulyanova, T., Kovalchuk, A., Dushayeva, L., Murzabayev, K., Taipova, A., Zholdasbekova, A. & Isabaev, A. (2023). Marking of Genetic Resistance to Chlamydia, Brucellosis and Mastitis in Holstein Cows by Using Polymorphic Variants of LTF, MBL1 and TLR9 Genes. American Journal of Animal and Veterinary Sciences, 18(2), 89-97. https://doi.org/10.3844/ajavsp.2023.89.97

Open AccessCopyright: © 2023 Indira Beishova, Birzhan Nurgaliyev, Alena Belaya, Gulzhagan Chuzhebayeva, Vadim Ulyanov, Tatyana Ulyanova, Alexandr Kovalchuk, Laura Dushayeva, Kenzhebek Murzabayev, Ainura Taipova, Aizhan Zholdasbekova and Azamat Isabaev. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • Cattle
  • Holstein Breed
  • Lactoferrin
  • Mannose-Binding Lectin
  • Toll-Like Receptors