EXERCISE TRAINING REVERSES THE DELETERIOUS EFFECT OF SUCROSE INTAKE ON INSULIN RESISTANCE AND VISCERAL FAT MASS DEPOSITION ON MICE

Abstract

Abnormal fat deposition has been identified as an important mechanism of obesity-associated with insulin resistance. Literature data also indicate that exercise can improve insulin action. The heme pathway enzyme δ-Aminolevulinate Dehydratase (δ-ALA-D) is a good marker for oxidative stress and this sulfhydryl enzyme is inhibited in such oxidative pathologies diabetes. The aim of this study was to evaluate the effects of physical exercise in mice fed high sucrose (20% in drinking water), on aspects of insulin resistance, profile of oxidative status in different tissues and influence on δ-ALA-D activity. Glucose (p<0.003), insulin (p<0.01) plasma levels and abdominal fat index (p<0.001) were significantly higher in mice fed the sucrose in the water when compared to control group. Not have difference on these parameters between exercised mice fed the sucrose and control group. Hepatic, ALA-D activity and TBARS from liver, kidney and brain, of sucrose fed animals with and without exercise were not different than that of control group. The results of the present study possibly indicate that the sucrose administration in the water, cause marked insulin resistance and that the physical exercise showed efficient in increase insulin sensibility in mice with insulin resistance.