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ISSN: 1553-619X (Print)
ISSN: 1558-3775 (Online)
Research Article Open Access

Use of an Extremely Biodiverse Probiotic and a Supplement Based on Microbial Chondroitin Sulfate is Associated with a Significant Decrease of Serum Free Kappa Light Chains as well as a Trend Toward Normalization of Kappa/Lambda Ratio and of Plasma Cell Bone Marrow Infiltration in a Case of Multiple Myeloma

Nicola Antonucci1, Stefania Pacini2 and Marco Ruggiero2
  • 1 Biomedical Centre for Autism Research and Treatment, Italy
  • 2 Silver Spring Sagl, Switzerland

Abstract

We describe the case of a 71-year-old woman with multiple myeloma associated with severe chronic renal insufficiency who, since October 2018, assumed a novel, extremely biodiverse, probiotic and a supplement based on microbial chondroitin sulfate, vitamin D3 and ultrapure phosphatidylcholine; such a nutritional regimen was associated with a dramatic decrease of serum free Kappa light chains (from 2,190 to a minimum of 119.40 mg/L) as well as a trend toward normalization of Kappa/Lambda ratio (from 187 to a minimum of 3.16) and of plasma cell bone marrow infiltration (from 20 to 5%).

American Journal of Immunology
Volume 15 No. 1, 2019, 5-9

DOI: https://doi.org/10.3844/ajisp.2019.5.9

Submitted On: 27 May 2019 Published On: 18 June 2019

How to Cite: Antonucci, N., Pacini, S. & Ruggiero, M. (2019). Use of an Extremely Biodiverse Probiotic and a Supplement Based on Microbial Chondroitin Sulfate is Associated with a Significant Decrease of Serum Free Kappa Light Chains as well as a Trend Toward Normalization of Kappa/Lambda Ratio and of Plasma Cell Bone Marrow Infiltration in a Case of Multiple Myeloma. American Journal of Immunology, 15(1), 5-9. https://doi.org/10.3844/ajisp.2019.5.9

Open AccessCopyright: © 2019 Nicola Antonucci, Stefania Pacini and Marco Ruggiero. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • Colostrum
  • Phages
  • Probiotic
  • Multiple Myeloma
  • Chondroitin Sulfate
  • Vitamin D3
  • Phosphatidylcholine
  • RAD52